论文部分内容阅读
经鼻粘膜给药容易吸收进入循环系统,且能使药物免于肝脏首过代谢。很多肽类药物可经鼻给药,但一些大分子化合物经鼻吸收的生物利用度明显降低,只有给予吸收增强剂,方可改善吸收情况。甘氨酸钠、月桂基硫酸钠、聚氧乙烯9月桂基醚(P9E)是三种能增加胰岛素在鼻腔吸收的佐药。本文以分子量分别为600,1000,2000的聚乙二醇(PEGs)为标记物,观察上述三种佐药影响鼠鼻粘膜对 PEGs 通透性的情况,同时取鼻粘膜做组织学检查,从而研究药物经鼻吸收的分子量依赖性。
Transnasal mucosal administration is readily absorbed into the circulatory system and prevents the drug from first-pass metabolism in the liver. Many peptide drugs can be administered nasally but the bioavailability of some macromolecular compounds via nasal absorption is significantly reduced. Only absorption enhancers are given to improve absorption. Sodium glycinate, sodium lauryl sulfate, polyoxyethylene 9 lauryl ether (P9E) are three adjuvants that increase insulin absorption in the nasal cavity. In this paper, polyethylene glycol (PEGs) with molecular weights of 600, 1000, and 2000 respectively were used as the markers to observe the permeability of nasal mucosa to PEGs in the three kinds of adjuvant. The histological examination of nasal mucosa Study drug molecularly dependent nasal absorption.