铜酞菁与半胱氨酸对甲基苄基亚硝胺引起大鼠食管上皮肿瘤有抑制作用。经过9个月的实验,甲基苄基亚硝胺对照组的食管肿瘤发生率为91.0%,而加入铜酞菁组与半胱胺酸组分别为58.8%和77.7%。对照组的食管乳头瘤癌变率为50%,铜酞菁组和半胱氨酸组均为14.3%,癌的发生率也比对照组低。对铜酞菁和半胱氨酸的作用机制进行了讨论。 Copper phthalocyanine and cysteine ​​p-methylbenzyl nitrosamine inhibited esophageal epithelial tumors in rats. After 9 months of experiments, the incidence of esophageal neoplasms in the methylbenzylnitrosamine control group was 91.0%, while those in the copper phthalocyanine group and the cysteine ​​group were 58.8% and 77.7%, respectively. The cancerous rate of esophageal papilloma in the control group was 50%, that of the copper phthalocyanine group and cysteine ​​group was 14.3%, and the incidence of cancer was also lower than that of the control group. The mechanism of action of copper phthalocyanine and cysteine ​​was discussed.