目的了解小儿轮状病毒肠炎患者血清肌酸激酶同工酶(CK-MB)的变化及其与小儿轮状病毒肠炎预后的关系。方法对2008-01-2009-12住院诊断为小儿轮状病毒肠炎的223例患儿CK-MB及预后进行回顾性分析。结果观察组223例小儿轮状病毒肠炎患儿中,CK-MB增高142例(63.68%),而对照组46例CK-MB均正常,差异有统计学意义(P<0.01)。观察组中,CK-MB正常组平均住院日(3.32±1.57)d,升高组平均住院日为(4.84±1.62)d。病程第7天观察疗效,CK-MB正常组治愈59例,好转22例,治愈率72.84%。CK-MB升高组治愈70例,好转72例,治愈率49.30%。两组比较,差异有统计学意义(P<0.05)。结论 CK-MB升高为小儿轮状病毒肠炎的常见并发症,提示患者常伴有心肌受损,患者平均住院日延长,7 d治愈率低于CK-MB正常者。 Objective To investigate the changes of serum creatine kinase (CK-MB) in children with rotavirus enteritis and its relationship with the prognosis of pediatric rotavirus enteritis. Methods A retrospective analysis of CK-MB and its prognosis in 223 children diagnosed as pediatric rotavirus enteritis between January 2008 and January 2009 was performed. Results Among 223 cases of children with rotavirus enteritis, CK-MB increased 142 cases (63.68%) in observation group and 46 cases CK-MB in control group were normal, the difference was statistically significant (P <0.01). In the observation group, the average length of stay of CK-MB in normal group was (3.32 ± 1.57) d, and the average length of stay in elevated group was (4.84 ± 1.62) d. The course of the first 7 days to observe the effect, CK-MB normal group cured 59 cases, improved in 22 cases, the cure rate was 72.84%. In CK-MB group, 70 cases were cured, 72 cases improved, the cure rate was 49.30%. The difference between the two groups was statistically significant (P <0.05). Conclusions The elevated CK-MB is a common complication of rotavirus enteritis in children, suggesting that patients with myocardial damage are often accompanied by an increase in the average length of stay in patients. The cure rate after 7 days is lower than that in patients with normal CK-MB.