论文部分内容阅读
目的应用Meta分析对脂肪细胞因子中的肿瘤坏死因子α、瘦素受体和脂联素基因多态性与2型糖尿病(T2DM)关联性进行综合评价。方法应用哈代-温伯格平衡对入选文献的基因型进行遗传平衡性检验,根据异质性检验结果选用固定或随机效应模型,采用Begg’s和Egger’s法对发表偏倚进行量化检测,应用RevMan 5.1软件进行Meta分析。结果共50篇文献符合条件纳入研究,纳入文献无明显发表偏倚;瘦素受体SNP-668A>G与T2DM的关联性差异无统计学意义;而肿瘤坏死因子αSNP-308G>A A对G等位基因的OR(95%CI)=1.38(1.11~1.71),GA+AA对GG基因型的OR(95%CI)=1.26(1.05~1.51),差异均有统计学意义(P<0.05);脂联素SNP+45T>G G对T等位基因的OR(95%CI)=1.17(1.03~1.33),GG+TG对TT基因型的OR(95%CI)=1.16(1.01~1.34),差异均有统计学意义(P<0.05)。结论瘦素受体SNP-668A>G基因多态性与T2DM无明显关联,而肿瘤坏死因子αSNP-308G>A和脂联素SNP+45T>G可能是T2DM的危险因素。
Objective To evaluate the association between TNFα, leptin receptor and adiponectin gene polymorphisms and type 2 diabetes (T2DM) in adipocytokines by Meta-analysis. Methods Genotypes of selected subjects were tested for genetic balance using Hardy - Weinberg equilibrium. Fixed or random effects models were selected based on heterogeneity test results. Begg ’s and Egger’ s methods were used to quantify the published biases. RevMan 5.1 software was used Meta analysis. Results A total of 50 articles were eligible for inclusion in the study and there was no published publication bias in the literature. There was no significant difference in the association of SNP-668A> G between leptin receptor and T2DM. Tumor necrosis factor alpha SNP-308G> OR (95% CI) was 1.38 (1.11-1.71). The OR (95% CI) of GA + AA for GG genotype was 1.26 (1.05-1.51), the difference was statistically significant (P <0.05). OR (95% CI) = 1.17 (1.03-1.33) for the T allele of adiponectin SNP + 45T> GG and 1.16 (1.01-1.34) for the TT genotype of GG + TG, The differences were statistically significant (P <0.05). Conclusion SNP-668A> G polymorphism of leptin receptor has no obvious correlation with T2DM. TNF-αSNP-308G> A and adiponectin SNP + 45T> G may be risk factors of T2DM.