最近的证据表明端粒酶活性为细胞永生态(immortality)所需,而细胞永生态又为维持大多数恶性肿瘤细胞的无限生长能力所必需。胃肠癌发病的步骤之一很可能是细胞获得永生态。为了了解胃肠癌恶性度的发生、发展是否取决于端粒酶活化并决定在癌变的哪一期细胞可检测到端粒酶活性,作者应用端粒重复扩增模型方法(TRAP)分析了胃、结直肠癌及其癌前病变中的端粒酶活性。 Recent evidence suggests that telomerase activity is required for the immortality of cells, and that the cells are ecologically necessary to maintain the unlimited growth capacity of most malignant cells. One of the steps for the onset of gastrointestinal cancer is likely to be the eugenicity of the cells. In order to understand whether the occurrence and development of gastrointestinal cancer depends on the activation of telomerase and determine which phase of cancer cells can detect telomerase activity, the authors analyzed the stomach using the TRAP model (TRAP). Telomerase activity in colorectal cancer and its precancerous lesions.