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The purpose of this study is to investigate the expression of estrogen receptor (ER) and P glycoprotein (Pgp) in human primary colorectal carcinoma and the relationship of ER and Pgp expressions with the biologic behaviors of the tumor. Sixty five patients undergoing colorectal cancer resection were enrolled. The case records and pathological reports were reviewed. Paraffin embedded tumor specimens from the 65 cases were examined. The expression of ER and Pgp were determined with immunohistological technique. The relationship between the expressions of ER and Pgp and clinical and pathological characteristics were evaluated. The investigations showed that the positive expression of ER and Pgp were detected in 75.4% and 73.8% of the tumor tissue respectively. The rates of positive expression of ER and Pgp were high in tumor tissues than in normal mucosa (P<0.05). ER expression in the tumor was independent of sex and age of the patients, size ,site and Duke′s stages of the tumors, so did the Pgp expression. The results show that ER and Pgp expression increased in the course of carcinogenesis of colorectal carcinoma. However, there was no strong evidence indicating that the expression of ER of Pgp was related to the clinical presentations and pathological stages.
The purpose of this study is to investigate the expression of estrogen receptor (ER) and P glycoprotein (Pgp) in human primary colorectal carcinoma and the relationship of ER and Pgp expressions with the biologic behaviors of the tumor. Sixty five patients undergoing colorectal cancer resection Were associated with the expressions of ER and Pgp and clinical and pathological characteristics were. The investigations showed that the positive expression of ER and Pgp were detected in 75.4% and 73.8% of the tumor tissue respectively. The rates of positive expression of ER and Pgp were high in tumor tissues than in normal mucosa (P<0.05). ER expression in the tumor was independent of sex and age of the patients, size , site and Duke’s stages of the tumors, so Did the Pgp expression. The results show that ER and Pgp expression increased in the course of carcinogenesis of colorectal carcinoma. However, there was no strong evidence indicating that the expression of ER of Pgp was related to the clinical presentations and pathological stages.