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目的探讨缬沙坦对高血压左室肥厚的逆转作用。方法应用24h动态血压监测和超声心动图技术评价缬沙坦对高血压患者的降压效果、对左室肥厚的逆转作用及左室收缩和舒张功能的研究,并与一代血管紧张素转换酶抑制剂卡托普利的作用进行比较。结果二者均能降低血压,逆转左室肥厚,改善左室收缩和舒张功能,但缬沙坦作用较卡托普利更明显。二者对心率和肾功能均无明显影响,提示二者在保护靶器官方面都有效果,但缬沙坦的效果更好。结论缬沙坦对肾素-血管紧张素系统有完全阻断作用,患者将在长期应用中获益,不仅高效降压,同时对靶器官有保护作用,能改善心功能,提高生活质量。
Objective To investigate the reversal effect of valsartan on left ventricular hypertrophy in patients with hypertension. Methods 24h ambulatory blood pressure monitoring and echocardiography were used to evaluate the antihypertensive effect of valsartan in patients with hypertension, reversal of left ventricular hypertrophy and left ventricular systolic and diastolic function, and with a generation of angiotensin converting enzyme inhibition The effect of captopril was compared. The results of both can lower blood pressure, reverse left ventricular hypertrophy, improve left ventricular systolic and diastolic function, but valsartan effect than captopril more obvious. Both had no significant effect on heart rate and renal function, suggesting that both of them have effects in protecting target organs, but valsartan is more effective. Conclusion Valsartan has a complete blocking effect on the renin-angiotensin system. Patients will benefit from long-term use of antihypertensive drugs. In addition, they will have a protective effect on target organs and improve heart function and quality of life.