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目的 优化阿昔洛韦白蛋白微球的制备工艺 ,并对其形态学性质、载药量、体外释药进行考察。方法 用乳化热固化法制备微球 ,用动态透析法进行体外释药。结果 微球平均粒径为 (0 .94± 0 .15 ) μm ,载药量为 (16 .0 7± 1.0 4) % ,体外释药方程 1-Q=0 .815e-0 .664 0 2t+0 .16 2 5e-0 .0 1657tt1/ 2α=1.0 44h ,t1/ 2 β=41.82h。结论 微球外观圆整、均匀 ,体外释药符合长效制剂的特征。
Objective To optimize the preparation process of acyclovir albumin microspheres and study its morphological properties, drug loading and drug release in vitro. Methods The microspheres were prepared by emulsification and thermal curing method and the drug was released in vitro by dynamic dialysis. Results The average diameter of the microspheres was (0.94 ± 0.15) μm, the drug loading was (16.07 ± 1.04)%, and the in vitro drug release equation was 1-Q = 0.81 5e-0 .664 0 2t +0 .16 2 5e-0 .0 1657tt1 / 2α = 1.0 44h, t1 / 2 β = 41.82h. Conclusion Microspheres appearance is round, uniform, in vitro release in line with the characteristics of long-acting formulations.