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目的 :本文采用 1 %麻黄素滴鼻方法治疗偏头痛患者 48例。方法 :通过脑阻抗血流图 (Reoencephalogram ,REG)进行了治疗前后的观察对比研究。结果 :发现麻黄素滴鼻对无先兆型和有先兆型偏头痛均有效。总有效率分别为 96 .8%和 82 .4% ,REG的流入时间、波幅、转折高比值、重搏波、波形及波幅差均见明显的变化。提示麻黄素自鼻粘膜吸收后 ,迅速作用于过度扩张的颅外血管 ,通过颅外和颅内血管间的交通 ,对颅内血管也具有一定的收缩作用。结论 :鼻腔给药有可能成为替代全身给药的重要途径之一
Objective: In this paper, 1% ephedrine nasal drops in the treatment of migraine patients in 48 cases. Methods: A comparative study was conducted by means of Reoencephalogram (REG) before and after treatment. Results: Ephedrine nasal drops were found to be effective for both aura and migraines. The total effective rates were 96.8% and 82.4% respectively. The inflows, amplitudes, transition height ratios, double-pacing, waveform and amplitude differences of REGs all showed obvious changes. Prompt ephedrine absorbed from the nasal mucosa, the rapid role in the excessive expansion of the extracranial blood vessels, intracranial and intracranial vascular traffic, on the intracranial vessels also have some systolic. Conclusion: Nasal administration may become one of the important alternative to systemic administration