酮康唑为有效的口服抗霉菌药及作用较强的性腺、肾上腺类固醇合成抑制荆。可通过干扰细胞色素 P-450酶系统而起作用。本文介绍酮康唑治疗34例 Cushing 综合征的经验。病人和方法 Cushing 综合征34例,男6例、女28例,平均年龄38.5(14～67)岁。其中28例为垂体依赖型,1例肾上腺腺瘤,2例原发双侧结节性肾上腺增生,1例肾上腺癌,2例异源 ACTH 综合征。每日服用酮康唑400～800mg,腺癌者用至1000～1200mg/d。前4周 Ketoconazole is an effective oral antifungal agent and has a strong effect on the synthesis of gonads and adrenal steroids. It works by interfering with the cytochrome P-450 enzyme system. This article describes the experience of ketoconazole in the treatment of 34 cases of Cushing syndrome. Patients and Methods There were 34 patients with Cushing syndrome, 6 males and 28 females, with an average age of 38.5 (14-67) years. Among them, 28 were pituitary dependent, 1 had adrenal adenoma, 2 had primary bilateral adrenal hyperplasia, 1 had adrenal gland cancer, and 2 had heterologous ACTH syndrome. Ketoconazole 400 to 800 mg daily, and adenocarcinomas up to 1000 to 1200 mg/d. 4 weeks before