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近年来,脑血管疾病的发病率越来越高,它严重地影响着人类的健康和寿命的延长。几十年来,人们对磷脂在磷脂酶A_2(PLA_2)作用下产生的花生四烯酸(arachidonic acid,AA)及其代谢产物前列腺素类(prostaglandins,PG)和白三烯类(leukotrienes,LT)在脑血管疾病中的地位进行了广泛的研究,已经证明,脑血管疾病与体内PGI_2/TXA_2平衡、LT的产生及其病理生理调节作用有着密切的关系。70年代以来,人们对磷脂在PLA_2作用下产生的另一代谢产物血小板激活因子(platelet activating factor,PAF)进行了广泛的
In recent years, the incidence of cerebrovascular diseases is getting higher and higher, which seriously affects human health and life expectancy. For decades, arachidonic acid (AA) and its metabolites prostaglandins (PG) and leukotrienes (LT) produced by phospholipids under phospholipase A2 (PLA2) The role of cerebrovascular disease in cerebrovascular disease has been extensively studied and it has been demonstrated that cerebrovascular disease is closely related to the balance of PGI 2 / TXA 2 and the production of LT and its pathophysiological regulation in vivo. Since the 1970s, another metabolite platelet activating factor (PAF) produced by phospholipids under the action of PLA 2 has been extensively studied