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探究枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停(AOP)效果及其用药安全性分析。选取2014年4月~2016年7月收治的60例原发性AOP早产儿为观察对象,按照随机数字表法将早产儿分为对照组和观察组,每组30例。对照组患儿则在常规治疗的基础上给予氨茶碱治疗:首剂5mg/kg静脉注射,12h后给予维持量2mg/(kg·次),Bid,静脉注射,当原发呼吸暂停消失5d后停药。观察组患儿常规治疗的基础上给予枸橼酸咖啡因治疗,首剂20mg/kg静脉注射,24h后给予维持量5mg/kg/d,qd,静脉注射,当原发AOP消失5d后停药。对比两组疗效及不良反应发生情况。观察组早产儿治疗总有效率为90.00%,与对照组(治疗总有效率73.33%)相当((Z=2.794,P>0.05)),其药物不良反应发生率(6.67%)与对照组(43.33%)比较明显低,差异有统计学意义(P>0.05)。枸橼酸咖啡因治疗原发性AOP的疗效显著,安全性高,应作为治疗原发性AOP的首选药物。
To explore the efficacy and safety of citrate caffeine and aminophylline in the treatment of premature infants with primary apnea (AOP). Sixty cases of primary AOP preterm infants admitted from April 2014 to July 2016 were selected as observation subjects. According to the random number table, preterm infants were divided into control group and observation group, 30 cases in each group. The control group was treated with aminophylline on the basis of conventional treatment: the first dose of 5mg / kg intravenous injection, 12h after the maintenance dose of 2mg / (kg), Bid, intravenous injection, when the primary apnea disappeared 5d After the withdrawal. The observation group was given routine treatment of citrulline citrate based on the first dose of 20mg / kg intravenous injection, 24h after the maintenance dose of 5mg / kg / d, qd, intravenous injection, when the primary AOP disappeared after 5d withdrawal . Compare the two groups of curative effects and adverse reactions. The total effective rate of premature infants in the observation group was 90.00%, which was comparable to that of the control group (total effective rate 73.33%) (Z = 2.794, P> 0.05). The adverse drug reaction rate was 6.67% 43.33%) was significantly lower, the difference was statistically significant (P> 0.05). Citrate caffeine treatment of primary AOP significant effect, high safety, should be used as the treatment of primary AOP drugs.