论文部分内容阅读
目的探讨儿童慢性乙型肝炎患者的基因型特征与病毒载量及肝组织病理的关系。方法随机采集临床确诊病例48例,进行HBV基因分型、HBV-DNA载量、肝组织病理学。结果 HBV基因型显示B型5例,HBVDNA为低载量,病理损害多为轻至中度。BC混合型4例,HBVDNA为低,中载量为主,病理损害多为轻至中度。C型39例,HBVDNA为高载量为主,病理损害多为中重度为主。结论儿童慢性乙型肝炎患者有明显的家族聚集性,以基因C型为主,病毒载量高,肝组织病理损伤较重,容易慢性化,预后不良。临床可视肝组织病理结果酌情抗病毒治疗。肝组织病理学检查作为患者治疗前常规检测手段,为规范慢性乙肝抗病毒治疗提供可靠依据。
Objective To investigate the relationship between genotype characteristics and viral load and liver histopathology in childhood chronic hepatitis B patients. Methods 48 cases of clinically confirmed cases were collected randomly for HBV genotyping, HBV DNA load and liver histopathology. Results HBV genotypes showed 5 cases of type B, with low HBV DNA load and mild to moderate pathological changes. BC mixed 4 cases, HBVDNA is low, mainly in the amount of load, mostly mild to moderate pathological damage. C type in 39 cases, HBVDNA is mainly high-load, mostly pathological lesions of moderate to severe. Conclusion Children with chronic hepatitis B have obvious familial aggregation, mainly genotype C, high viral load, severe pathological damage of liver tissue, easy to chronic, poor prognosis. Clinical visualization of liver pathology results appropriate antiviral therapy. Liver histopathology as a routine test before treatment, to provide a reliable basis for the regulation of chronic hepatitis B antiviral therapy.