目的比较胰腺、肾脏在单独和联合移植中排斥反应的差异。方法在大鼠同种异体单独胰腺移植、单独肾脏移植和胰肾联合移植基础上，对胰腺、肾脏在单独和联合移植中的排斥反应分别进行了比较。结果（１）胰腺在联合肾脏移植中受到肾脏保护，与单独移植相比，功能与形态学指标得到显著改观；（２）肾脏在联合胰腺移植时未受到胰腺保护，与单独移植比较，各项指标未得到显著改善。结论胰腺与肾脏联合移植的结局优于单独胰腺移植，而肾脏单独与联合移植的结局相似 Objective To compare the differences in rejection between the pancreas and kidney in single and combined transplantation. Methods The rejection of pancreas and kidneys in single and combined transplantation were compared respectively in rats after allogeneic pancreas transplantation, kidney transplantation alone and pancreas-kidney transplantation. Results (1) The pancreas was protected by the kidneys in combination with renal transplantation. The function and morphology of the pancreas were significantly improved compared with the single transplantation. (2) Compared with the single transplantation, the kidneys were not protected by pancreas in the united pancreas transplantation. Indicators have not been significantly improved. Conclusions The outcome of combined pancreas and kidney transplantation is superior to that of pancreas transplantation alone, while the outcome of kidney transplantation alone and in combination is similar