胰岛素依赖性糖尿病(IDDM)以某些胰岛细胞抗原(包括谷氨酸脱羧酶)的自身抗体为特征。作者试图查明是否在对谷氨酸脱羧酶的反应中外周血单核细胞(PBMC)的增殖与胰岛素依赖性糖尿病有关。作者研究了新近诊断的 IDDM 病人、有或没有胰岛细胞自身抗体(ICA)的糖尿病病人的亲属以及随意选择的健康对照者周围血的单核细胞。结果显示,单核细胞对重组谷氨酸脱羧酶抗原产生阳 Insulin-dependent diabetes mellitus (IDDM) is characterized by autoantibodies to certain islet cell antigens, including glutamate decarboxylase. The authors sought to determine whether proliferation of peripheral blood mononuclear cells (PBMCs) is associated with insulin-dependent diabetes in response to glutamate decarboxylase. The authors studied newly diagnosed patients with IDDM, relatives of diabetic patients with and without islet cell autoantibodies (ICA), and mononuclear cells from peripheral blood of randomly selected healthy controls. The results show that mononuclear cells produce positive for recombinant glutamate decarboxylase antigens