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目的：研究猕猴桃果汁抗环磷酰胺（ＣＰ）的致突变作用及其可能的作用机制。方法：测定大鼠外周血双核淋巴细胞微核细胞率及肝中超氧化物歧化酶（ＳＯＤ）活性，还原型谷光甘肽（ＧＳＨ）、丙二醛（ＭＤＡ）含量。结果：猕猴桃果汁对ＣＰ诱发的大鼠外周血双核淋巴细胞微核细胞率有显著抑制作用，能明显诱导大鼠肝ＳＯＤ活性增强，以及ＧＳＨ的含量增加，降低ＭＤＡ含量。大鼠外周血双核淋巴细胞微核细胞率与ＳＯＤ活性及ＧＳＨ含量呈明显负相关，与ＭＤＡ含量呈明显正相关。结论：猕猴桃果汁抗ＣＰ致微核形成作用的机制可能与通过提高机体抗氧化防御系统的功能，防止有害自由基对细胞内生物大分子的损伤有关。
Objective: To study the mutagenic effect of kiwifruit juice against cyclophosphamide (CP) and its possible mechanism. Methods: The peripheral blood micronuclear cell micronucleus cell rate, superoxide dismutase (SOD) activity in the liver, reduced glutathione (GSH) and malondialdehyde (MDA) content were measured. RESULTS: Kiwi juice had a significant inhibitory effect on the rate of peripheral blood mononuclear lymphocyte micronuclear cells induced by CP, and it could obviously induce the increase of liver SOD activity, increase of GSH content, and decrease of MDA content. The rate of micronuclei in peripheral blood lymphocytes was significantly negatively correlated with SOD activity and GSH content in rat peripheral blood and positively correlated with MDA content. Conclusion: The mechanism of anti-CP micronucleus formation in kiwifruit juice may be related to the prevention of harmful free radicals damage to intracellular biological macromolecules by improving the function of the body’s antioxidant defense system.