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目的探讨慢性乙型病毒性肝炎肝细胞内HBsAg、HBcAg的表达与肝组织病理学的关系。方法对146例慢性乙型病毒性肝炎肝细胞内HBsAg、HBcAg的表达和肝组织病理学进行回顾性分析。结果 146例慢性乙型病毒性肝炎肝细胞内HBsAg、HBcAg的表达率分别为89.0%和80.8%,肝细胞HBc Ag胞桨阳性、胞桨+胞核阳性、胞核阳性的慢性乙型病毒性肝炎患者中,中度和重度炎症活动度的比例分别为75.0%、23.1%和8.3%;纤维化S0-S2、S3-S4的比例分别为50.0%、50.0%,73.1%、26.9%,86.1%、13.9%。结论慢性乙型病毒性肝炎肝细胞内HBsAg的表达是慢性HBV感染的一个标志,肝细胞内HBcAg的表达方式与肝组织炎症分级和纤维化分期相关,HBcAg胞桨阳性的慢性乙型病毒性肝炎患者组炎症活动度和纤维化程度,均显著高于HBcAg胞核阳性和胞核+胞桨阳性的慢性乙型病毒性肝炎患者组。
Objective To investigate the relationship between the expression of HBsAg and HBcAg in hepatocytes and the histopathology of liver in chronic hepatitis B patients. Methods The expression of HBsAg and HBcAg in liver cells of 146 patients with chronic hepatitis B and the histopathology of liver were analyzed retrospectively. Results The positive rates of HBsAg and HBcAg in hepatocytes of 146 patients with chronic hepatitis B were 89.0% and 80.8%, respectively. The positive cells of paddle + nucleus of HBcAg were positive for hepatocytes, while the nuclei positive for chronic hepatitis B The proportions of moderate and severe inflammatory activity were 75.0%, 23.1% and 8.3% in patients with hepatitis and 50.0%, 50.0%, 73.1%, 26.9% and 86.1 %, 13.9%. Conclusions The expression of HBsAg in hepatocytes of patients with chronic hepatitis B is a sign of chronic HBV infection. The expression of HBcAg in hepatocytes is related to the grade of inflammation and the stage of fibrosis in hepatocytes. The positive rate of HBcAg-positive chronic hepatitis B The degree of inflammatory activity and fibrosis in patients were significantly higher than those in HBcAg-positive and nucleus + pad-positive chronic hepatitis B patients.