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氟虫腈是第一个商品化的苯基吡唑类杀虫剂,其作用机理是抑制γ-氨基丁酸(GABA)受体氯离子通道.氟虫腈为防治一些世界性的重大害虫包括对以前使用的杀虫剂具有严重抗性的害虫作出了重要贡献.然而,随着氟虫腈的大量使用,害虫对该药的抗药性问题受到日益关注.至今,重要的农业害虫如小菜蛾,烟粉虱、褐飞虱、白背飞虱,二化螟及斜纹夜蛾等已经对氟虫腈产生抗药性.文章就害虫对氟虫腈的抗药性发生概况、交互抗性及抗药性机理策略进行综述,以期为氟虫腈的合理使用提供理论基础.“,”Fipronil is the first commercially used member of the phenylpyrazole insecticides that interact antagonistically with GABA-gated chloride channel. Fipronil has made a great contribution to manage some of the most destructive crop pests in the world, including species with serious resistance to earlier-used insecticides. However, with the extensive application in pest control, the great attention has been paid to the resistance of insects to fipronil. To date, some substantial agricultural pests such as Plutella xylostella (L.), Bemisia tabaci (Gennadius), Nilaparvata lugens ( Stal), Sogatella furcifera ( Horváth ) , Chilo suppressalis ( Walker) , Spodoptera litura (Fabricius) , etc, have developed resistance to fipronil. To provide a theory base for reasonable using fipronil, current status of resistance, cross-resistance, and resistance mechanism were reviewed in this article.