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目的探讨门诊全程督导治疗耐多药肺结核病的方法、药物不良反应和治疗效果。方法利用世行贷款结核病免费治疗督导点对耐多药肺结核病人实行全程督导治疗。结果本文38例耐多药肺核病患者均按规定全程规则治疗满18个月疗程。3月末痰菌阴转率为57.8%,6月末为86.8%,完成18个月疗程后其痰菌阴转率为92.1%。放射学完成疗程后病灶明显吸收率为81.5%,吸收率为97.3%。不良反应中表现为胃肠道反应者39.4%,肝功能损害15.7%,神经精神系统反应者15.7%。结论门诊全程督导治疗耐多药结核病规则治疗率和治愈率高,副反应轻微,治疗费用低,可被大多数患者所接受,值得临床研究推广。
Objective To explore the methods of supervision and treatment of multidrug-resistant pulmonary tuberculosis in clinic, adverse drug reactions and therapeutic effects. Methods Using the free treatment guideline of World Bank Loan Tuberculosis Treatment Center to carry out the whole supervision and treatment of MDR-TB patients. Results 38 cases of MDR-TB patients were treated according to the rules of the full course of treatment for 18 months course. The sputum negative conversion rate was 57.8% at the end of March, 86.8% at the end of June. After 18 months of treatment, the sputum negative conversion rate was 92.1%. Radiotherapy after the completion of the lesion apparent absorption rate was 81.5%, the absorption rate was 97.3%. Adverse reactions showed 39.4% of gastrointestinal reactions, liver damage 15.7%, 15.7% of neuropsychiatric patients. Conclusion The outpatient supervision and treatment of multidrug-resistant tuberculosis with regular treatment rate and high cure rate, minor side effects, low cost of treatment, which can be accepted by most patients, is worth to promote clinical research.