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ｎｅｕ基因编码一种和表皮生长因子受体同源的磷酸蛋白，具有酪氨酸激酶的活性．近年来在多种人类肿瘤中发现ｎｅｕ基因的扩增和（或）过量表达．一些蛋白质因子或化学药物可以在转录水平阻遏ｎｅｕ基因的过量表达或者降低其产物ｐ１８５ｎｅｕ的酪氨酸激酶活性，抑制具有ｎｅｕ基因过量表达的癌细胞的转移和增殖．
The neu gene encodes a phosphoprotein homologous to the epidermal growth factor receptor and has tyrosine kinase activity. In recent years, amplification and (or) overexpression of the neu gene has been found in many human tumors. Some protein factors or chemicals can suppress the overexpression of the neu gene at the transcriptional level or reduce the tyrosine kinase activity of its product p185neu and inhibit the metastasis and proliferation of cancer cells with overexpression of the neu gene.