近年来,婴儿胆汁郁积综合征(以下称胆汁郁积)已受到临床上极大关注。生理学上,胆汁郁积规定为形成受损,或从胆汁产生处到它引流至十二指肠的任何部位受损。有时用梗阻性黄疸的概念代替胆汁郁积是不恰当的,因为本症并不始终有高胆红素血症,而且证明,在许多病例不存在机械性梗阻。本文之目的是使临床医生对本症的病因学和病理生理学观点有一个新的认识,并介绍目前有关诊断和治疗的知识。 In recent years, infant cholestasis syndrome (hereinafter referred to as cholestasis) has received great clinical attention. Physiologically, cholestasis is prescribed to be impaired in formation or impaired from the site of bile production to where it drains to the duodenum. Sometimes the concept of obstructive jaundice instead of cholestasis is not appropriate, because the disease does not always have hyperbilirubinemia, and proved that in many cases there is no mechanical obstruction. The purpose of this article is to give clinicians a new understanding of the etiology and pathophysiology of the disease and to present the current knowledge about diagnosis and treatment.