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目的探讨在初诊2型糖尿病患者中检测胰岛自身抗体,从而筛查出1型糖尿病,为糖尿病正确分型、指导临床用药以及判断预后提供依据。方法采用随机分组方法分为糖尿病组和正常对照组。对比两组的血清GAD-Ab、IAA、ICA检出率及三种抗体联合检出率。结果本组在初诊断的2型糖尿病患者中GADA检出阳性率为14.1%,三种抗体联合检出率为10.9%,明显高于对照组。结论GAD-Ab可以作为初诊2型糖尿病筛查1型糖尿病首选指标,多种抗体联合检测可以提高诊断的敏感性。
Objective To explore the detection of islet autoantibodies in patients with newly diagnosed type 2 diabetes so as to screen out type 1 diabetes and provide the basis for correct typing of diabetes, clinical medication and prognosis. Methods Randomly divided into diabetic group and normal control group. The serum GAD-Ab, IAA, ICA detection rates and the combined detection rate of three antibodies were compared between the two groups. Results The positive rate of GADA in newly diagnosed type 2 diabetes mellitus patients was 14.1%. The combined detection rate of the three antibodies was 10.9%, which was significantly higher than that of the control group. Conclusion GAD-Ab can be used as the first choice of screening type 1 diabetes mellitus for newly diagnosed type 2 diabetes. Combined detection of multiple antibodies can improve the diagnostic sensitivity.