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目的:探讨胃癌组织中血管内皮生长因子(VEGF)的表达与临床病理特点之间的关系.方法:应用SP免疫组化方法检测100例胃癌及50例胃良性病变标本中VEG的表达,并结合临床病理特点进行分析.结果:胃癌组织中VEGF阳性表达率75%(75/100),良性病变14%(7/50)(x~2=50.0323,P<0.001).VEGF阳性表达率与瘤体的大小、分化程度无关(P>0.05);与浆膜浸润、淋巴结转移TNM分期有关(P<0.001).结论:VEG在肿瘤生长中刺激新生血管生成.与胃癌的恶性进程密切相关,是胃癌的生物学标记.
OBJECTIVE: To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and clinicopathological features in gastric carcinoma.Methods: The expression of VEGF in 100 specimens of gastric cancer and 50 specimens of gastric benign lesions was detected by SP immunohistochemistry The clinicopathological features were analyzed.Results: The positive expression rates of VEGF in gastric cancer tissues were 75% (75/100) and benign ones were 14% (7/50) (x ~ 2 = 50.0323, P <0.001) (P <0.001) .Conclusion: VEG can stimulate neovascularization in tumor growth, which is closely related to the malignant process of gastric cancer and is Biological markers of gastric cancer.