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目的：探讨抗骨质疏松治疗对膝关节骨性关节炎患者全膝关节置换术后的临床效果的影响。方法选取2011年2月至2014年4月行单侧全膝关节置换术的37例膝关节骨性关节炎患者，根据术前术后有无进行系统抗骨质疏松治疗分为 A 组（抗骨质疏松治疗组）和 B 组（对照组）；对两组患者的术前、术后视觉模拟（VAS）评分、骨密度和膝关节 HSS 评分进行比较分析。结果两组患者术后 VAS 评分较入院时均明显下降，但 A 组在术后、术后6个月及末次随访时 VAS 评分均较 B 组更低（ P <0.05或 P <0.01）；A 组患者术后6个月及末次随访时骨密度较 B 组明显增高（ P <0.01）；A 组患者术后6个月及末次随访时膝关节 HSS 评分较 B 组更优（ P <0.05）。结论对预行全膝关节置换术的膝关节骨性关节炎患者行术前术后系统抗骨质疏松治疗可明显减轻患者术后疼痛，增加患者的骨密度，防止骨质疏松加重，更益于患者术后早期活动及膝关节功能恢复，是一种有效、安全且必要的治疗。“,”Objecfive To evaluate the clinical efficacy of anti - osteoporosis treatment in treatment of the patients with osteoarthritis of the knee total knee replacement surgery. Methods 37 cases of patients underwent unilateral total knee arthroplasty with knee osteoarthritis from Feb-ruary 2011 to April 2014 were selected in our therapy group. According to the presence or absence of preoperative and postoperative anti - osteopo-rosis treatment,they were divided into group A(anti - osteoporosis treatment group)and group B(control group). Preoperative and postoperative visual analog(VAS)score,bone density and HSS scores between the two groups were compared. Results The postoperative VAS scores were significantly lower when compared with admission,but group A postoperatively,after 6 months and last follow - up VAS scores were lower than group B( P < 0. 05 or P < 0. 01). BMD of patients in group A was significantly higher than that in group B after six months and last follow - up ( P < 0. 01);HSS score of group A was better than that of group B after six months and last follow - up( P < 0. 05). Conclusion The patients with knee osteoarthritis underwent total knee arthroplasty after the anti - osteoporosis treatment can significantly reduce postoperative pain and in-crease the patient′s bone density and prevent osteoporosis increased,more benefits the early postoperative activity of the patients and knee function recovery. It is an effective,safe and necessary treatment.