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乳腺癌是女性最常见的癌症,其发病率居女性恶性肿瘤首位~([1])。《乳腺癌HER2检测指南》(2014版)明确指出,推荐采用免疫组化法检测Her2蛋白的表达水平。手术标本的充分、及时和规范的固定是保障乳腺癌Her2检测质量的基础,固定不当可引起细胞、组织抗原的活性降低和定位不准确,进而影响Her2蛋白的检测与判读。甲醛固定液渗透能力约为1 mm/h,其固定液所需量可能因为检测抗原的不同而有差异。王银萍等~([2])认为,在病理标本的制作中,固定液的体积至少仍应>5倍于所浸泡组织
Breast cancer is the most common form of cancer in women, with the highest incidence of female malignancies ~ ([1]). The HER2 Detection Guide for Breast Cancer (2014 Edition) clearly states that Her2 protein expression is recommended by immunohistochemistry. The sufficient, timely and standardized fixation of the surgical specimens is the basis for the quality assurance of Her2 detection in breast cancer. Improper fixing can cause the decrease of the activity of the cells and tissue antigens and the inaccurate positioning, thereby affecting the detection and interpretation of the Her2 protein. Formaldehyde fixative penetration of about 1 mm / h, the amount of its fixing solution may be due to the detection of antigen differences. Wang Yinping et al ~ ([2]) that in the production of pathological specimens, the volume of fixed fluid should still be at least> 5 times the soaked tissue