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目的探讨妊娠高血压综合征(妊高征)并发肝损害病例的临床特点,症状、高血压的程度等因素与肝损害的相关性。方法对我院32例妊高征合并肝损害病例进行回顾性分析;根据患者的症状、水肿等的严重程度进行评分并与对照组(无肝损害的妊高症患者)比较。结果502例妊高征并发肝损害32例,肝损害多表现为血清转氨酶的轻、中度升高;与对照组比较,并发肝损害组ALB水平显著降低,凝血指标、肾功能两组间并无显著性差异;并发肝损害组的症状、高血压的程度的评分高于对照组,差异具有显著性(P<0.05);而水肿、24 h尿蛋白定量的评分两组间无显著性差异。结论妊高征并发肝损害多表现为轻、中度肝功能异常;肝损害多见于临床症状较重、血压明显升高的病例较多。
Objective To investigate the clinical features, symptoms, the degree of hypertension and other factors associated with liver damage in pregnancy-induced hypertension syndrome (PIH) complicated with liver damage. Methods A retrospective analysis was performed on 32 cases of PIH with liver damage in our hospital. The patients were scored according to the severity of their symptoms and edema, and compared with those of the control group (those without PIH). Results 502 cases of PIH complicated with liver damage in 32 cases, liver damage manifested as mild to moderate serum aminotransferase; Compared with the control group, the level of ALB in patients with liver injury significantly decreased, coagulation index, renal function and There was no significant difference between the two groups. The scores of symptoms and hypertension in patients with liver damage were higher than those in control group (P <0.05), while those in edema and 24 h urine protein did not show significant difference . Conclusion Pregnancy-induced hypertension complicated with liver damage mostly showed mild to moderate hepatic dysfunction. Liver damage was more common in patients with severe clinical symptoms and high blood pressure.