本文报导一例32岁男性疱疹样皮炎患者用氨苯砜治疗而发生周围神经病。神经科检查显示多发性神经病变,侵犯中枢神经及尺神经,以及比较少的其他周围神经。在停用氨苯砜后全部受损神经完全恢复功能。原因系由于氨苯砜的严重付作用,它侵犯周围神经在文献上是少有报导的。一般在应用砜类药时常见血液学上的改变,如嗜中性白细胞减少;颗粒性白细胞缺乏症;溶血;正铁血红旦白症。而砜类药物的反应也包括食欲缺乏,黄疸,皮肤发疹,精神病及头痛。有些神经病可以是砜类药物的急性并发症,如麻风病人用砜类药治疗,在瘤型麻风初次用药 This article reports a 32-year-old man with herpes dermatitis treated with dapsone and peripheral neuropathy. Neurological examination showed multiple neuropathies, violations of the central and ulnar nerves, and fewer other peripheral nerves. After discontinuation of dapsone all damaged nerves fully restored function. The reason for this is due to the serious side effects of dapsone, which violates the peripheral nerves is rarely reported in the literature. Commonly used in the application of sulfone drugs when the common hematological changes, such as neutropenia; granulocytic leukemia; hemolysis; orthokeratosis. The reaction of sulfone drugs also includes lack of appetite, jaundice, skin rash, mental illness and headache. Some neuropathy can be acute complications of sulfone drugs, such as leprosy patients with sulfone treatment, the first time in the anemia leprosy