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19例肺癌患者接受了术前PDT与外科手术的联合治疗。术前PDT是为了扩大手术适应证和缩小手术范围。9例属Ⅰ期,1例属Ⅱ期,8例Ⅲ期,1例Ⅳ期。2例是浸润到气管的表浅性病变,3例是浸润到气管分叉部息肉样或表浅性病变,11例是浸润到主支气管的息肉样或表浅性病变,3例是同时发生的多发癌。静脉注射HPD48～72小时后用Ar~+染料激光进行照射。治疗条件:表浅性病灶60～600J/cm~2,息肉样病变输出为200～800mW,照射8～15分钟。PDT后2—4周行外科手术。19例中有15例达预期目的:6例原不能手术的病例,有5例经PDT后能够手术;原拟肺叶切除的13例中有10例经PDT后手术范围缩小。若能选择性地进行术前PDT,就能谋求改善外科治疗的质量。
Nineteen lung cancer patients received a combination of preoperative PDT and surgery. Preoperative PDT is intended to expand surgical indications and narrow the scope of surgery. 9 cases belonged to stage I, 1 case belonged to stage II, 8 cases were stage III, and 1 case was stage IV. Two cases were superficial lesions that infiltrated into the trachea, three cases were polypoid or superficial lesions that infiltrated into the trachea bifurcation, 11 cases were polypoid or superficial lesions that infiltrated into the main bronchus, and three cases were concurrent. Multiple cancers. 48 to 72 hours after the intravenous injection of HPD, irradiation with an Ar~+ dye laser was performed. Treatment conditions: superficial lesions 60 ~ 600J/cm ~ 2, polypoid lesions output 200 ~ 800mW, irradiation 8 ~ 15 minutes. Two to four weeks after PDT surgery. Fifteen of the 19 patients achieved the intended goal: 6 were originally inoperable, and 5 were able to undergo surgery after PDT; 10 of the original 13 patients undergoing lobectomy had reduced surgical range after PDT. If preoperative PDT can be performed selectively, the quality of surgical treatment can be improved.