在工业生产中,有些化学致癌物质作用于机体组织,可以引起肿瘤的发生。早在1775年,Port 报告阴囊癌较多见于清扫烟囱工人中,认为它是由于煤烟沉积在阴囊皮肤绉折中所引起。这一发现向医学界第一次提出了职业性肿瘤问题。1875年及1876年,Volkmann 发现接触煤中的蜡质和焦油都可以引起皮肤肿瘤。近百年来,各国工业发展 In industrial production, some chemical carcinogens act on the body tissue and can cause tumors to occur. As early as 1775, Port reported that scrotal cancer was more likely to be seen in the sweeping chimney workers, which was thought to be caused by the deposition of soot in the scrotal skin. This discovery raised the issue of occupational cancer for the first time in the medical community. In 1875 and 1876, Volkmann found that exposure to wax and tar in coal can cause skin tumors. In the past 100 years, the industrial development of various countries