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双氯芬酸钾(Diclofenac Potassium,DK)是由汽巴—嘉吉公司研制的非甾体抗炎镇痛药。临床上主要用于非风湿性急性疼痛的短期治疗,同时以其快速镇痛、抗炎和抗渗出作用特点著称于世。本试验采用HPLC法测定男性健康志愿者口服双氯芬酸钾国产片和进口片后的血药浓度,对两者的药物动力学参数和生物利用度进行了比较,为临床合理用药提供科学
Diclofenac Potassium (DK) is a non-steroidal anti-inflammatory analgesic developed by Ciba-Cargill. Clinically for the short-term treatment of acute rheumatic pain, at the same time with its rapid analgesic, anti-inflammatory and anti-exudation features known to the world. In this study, HPLC method was used to determine plasma concentrations of domestic and imported tablets of diclofenac potassium in male healthy volunteers. The pharmacokinetic parameters and bioavailability of the two drugs were compared to provide scientific basis for clinical rational drug use