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用薄层层折法直接测定家兔经耳静脉注射山莨菪碱后不同时间的血药浓度,计算一次参数和二次参数,其消除相半衰期为15.8min,分布相半衰期为0.99min。与毒效学方法测得结果进行此较,结果证明,两法除药动学参数和其单位的具体意义不同外,其效应动力学与代谢动力学过程基本一致。两法结果均属二房室模型,分布速率远大于消除速率,消除半衰期和分布半衰期的比值分别为15.9和15.3,说明该药效应动力学可以反映出药物代谢动力学的基本过程。
The plasma concentration of different concentrations of anisodamine in rabbits after intravenous injection was measured by TLC. The first-order and second-order parameters were calculated. The elimination half-life was 15.8 min and the distribution half-life was 0.99 min. Compared with the results measured by toxicological methods, the results show that the two methods except pharmacokinetic parameters and the specific significance of their units are different, the effect of kinetics and metabolic dynamics process is basically the same. The results of the two methods belong to the two-compartment model. The distribution rate is far greater than the elimination rate, the elimination half-life and the distribution half-life ratio respectively 15.9 and 15.3, indicating that the pharmacodynamic effects can reflect the basic process of pharmacokinetics.