【摘 要】
：
Romipeptides A and B (1 and 2),two new romidepsin derivatives,and three known compounds,chromopeptide A (3),romidepsin (4) and valine-leucine dipeptide (5) were isolated from the fermentation broth of Chromobacterium violaceum No.968.Their structures were
【机 构】
：
State Key Lab of New Drug &Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Ch
论文部分内容阅读
Romipeptides A and B (1 and 2),two new romidepsin derivatives,and three known compounds,chromopeptide A (3),romidepsin (4) and valine-leucine dipeptide (5) were isolated from the fermentation broth of Chromobacterium violaceum No.968.Their structures were elucidated by interpretation of their UV,HR-ESI-MS and NMR spectra.The absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction analysis.Compounds 1-5 were evaluated for their anti-proliferative activities against three human cancer cell lines,SW620,HL60,and A549.The results showed most of these compounds exhibited antitumor activities in vitro,in which compound 2 displayed potent cytotoxicity to SW620,HL60 and A549 cell lines,with IC50of 12.5,6.7 and 5.7 nmol.L-1,respectively.
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