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糖尿病已经成为动脉粥样硬化和冠心病最重要的危险因子。强化血糖控制降低了糖尿病患者心血管病和其他并发症的发生率,但是仍不能有效预防其并发症的发生。经皮冠状动脉介入治疗的不断成熟,药物洗脱支架和联合高效抗凝药的应用,使糖尿病患者从中受益,但是糖尿病患者术后靶病变重建、心源性死亡、心肌梗死的发生率仍明显高于非糖尿病患者。近年来关于糖尿病加速冠脉病变发生发展机制的研究有许多新的进展,现从分子机制方面加以阐述。
Diabetes has become the most important risk factor for atherosclerosis and coronary heart disease. Intensive glycemic control reduces the incidence of cardiovascular disease and other complications in patients with diabetes, but still can not effectively prevent the occurrence of complications. Percutaneous coronary intervention of the growing maturity, drug-eluting stent and the combination of highly effective anticoagulant drugs, so that patients with diabetes benefit, but the target of diabetic patients after reconstruction, cardiac death, the incidence of myocardial infarction was still significant Higher than non-diabetic patients. In recent years, there have been many new advances in the research on the mechanism of diabetes in accelerating the development of coronary artery disease. Now we elaborate on the molecular mechanism.