五十年代已研究证实,乙氨嘧啶可以阻断间日疟原虫孢子增殖,但对该药在阳断孢子增殖过程中的作用部位至今尚有不同意见。由于用作间日疟预防时,体内含有卵囊的媒介按蚊多可再次吸到含有该药的人血,因而,对其孢子增殖期的作用部位确属值得研究。1975年12月我们曾以鸡疟原虫作模型,观察乙氮嘧啶在白纹伊蚊体内形成卵囊前后的作用,报道如下. In the 1950s, it has been confirmed that pyrimethamine can block the multiplication of P. vivax spores, but there are different opinions on the site of action of this drug during the process of yingpu spore proliferation. Because of the use of P. vivax in the prevention of Plasmodium vivax, an Anopheles sinensis containing oocysts in the body may be able to reabsorb human blood containing the drug once and for all. In December 1975 we have used the chicken malaria parasite as a model to observe the role of pyrimethanil in the formation of oocysts in Aedes albopictus before and after the role, reported as follows.