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目的分析乙型肝炎病毒携带者HBVDNA定量水平不同情况下的妊娠结局。方法对HBV携带孕产妇456人发生产科并发症包括羊水过少、产后出血、胎儿窘迫、妊娠期高血压疾病和早产的机率进行回顾统计分析。与正常孕产妇对照。将HBV携带孕产妇按HBVDNA定量水平分为三组;HBVDNA≤104、HBVDNA=104-7、HBVDNA≥108,进行三组间产科并发症发生率对照。结果 HBV携带孕产妇发生羊水过少、产后出血、妊娠期高血压疾病的机率较正常产妇高;HBV携带孕产妇C组发生羊水过少、产后出血和妊娠期高血压疾病机率较A和B组明显升高。结论检测HBVDNA定量水平,加强对HBV携带孕产妇的保健和治疗工作是非常必要的。
Objective To analyze the pregnancy outcome under different conditions of HBV DNA levels in patients with hepatitis B virus infection. Methods A retrospective statistical analysis was conducted on 456 maternal pregnant women with HBV associated obstetric complications including oligohydramnios, postpartum hemorrhage, fetal distress, gestational hypertension and preterm birth. Compared with normal pregnant women. HBV-carrying pregnant women according to the quantitative level of HBVDNA is divided into three groups; HBVDNA≤104, HBVDNA = 104-7, HBVDNA≥108, the incidence of obstetric complications among the three groups. Results HBV-carrying pregnant women had oligohydramnios, postpartum hemorrhage and pregnancy-induced hypertension were more likely than normal women. In HBV-infected pregnant women, oligohydramnios, postpartum hemorrhage and gestational hypertension were more likely than those in A and B Significantly increased. Conclusion It is very necessary to detect the level of HBVDNA and strengthen the care and treatment of HBV-carrying pregnant women.