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本文采用Ｈｏｗｅｌｌ氏一步法，对２０例子宫内膜腺癌与１０例子宫内膜增殖症嗜银蛋白（ＡｇＮＯＲ）定量研究，作单纯计数、团块形及不规则形颗粒计数，结果ＡｇＮＯＲｓ均数（ｘ±ｓ），增殖症组（５．０６±０．６６、０．７１±０．４７、０．８１±０．４７），腺癌组（６．３５±０．８８、２．４５±０．９２、２．６２±１．１０），两组间均有显著意义（ｐ＜０．０１）。从颗粒计数、大小形状及分布位置等来判断子宫内膜的良恶性及肿瘤的分级有一定价值。但高分化腺癌与腺瘤型、非典型增生组，上述结果则无显著差异（ｐ＞０．０５），提示ＡｇＮＯＲ定量对两者的鉴别并非可靠，必须结合病理组织学形态、免疫组化ＣＥＡ和其它有关辅助研究手段，则更有价值。然而，研究结果却揭示了腺瘤型、非典型增生具有一定的恶变率，可用其检测此类癌前病变。
In this paper, we use Howell’s one-step method to quantitatively study 20 cases of endometrial adenocarcinoma and 10 cases of endometrial proliferative Agarose, count as simple counts, agglomerates and irregular shaped particles, the results of AgNORs (X ± s), proliferative group (5.06 ± 0.66,0.71 ± 0.47,0.81 ± 0.47), adenocarcinoma group (6.35 ± 0.88,2.45 ± 0.92,2.62 ± 1.10). There was significant difference between the two groups (p <0.01). Judging from the particle count, size, shape and distribution of the location of the endometrial benign and malignant tumor grade has some value. However, there is no significant difference between the above-mentioned results and the well-differentiated adenocarcinoma (P> 0.05), suggesting that AgNOR quantification is not reliable for the identification of the two, and must be combined with histopathological features, immunohistochemistry CEA and other supporting research tools, it is more valuable. However, the findings revealed adenoma, atypical hyperplasia has a certain rate of malignancy, which can be used to detect such precancerous lesions.