Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 ex

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：gunnie0095

【摘要】

：

Accumulating evidence suggests that β-amyloid (Aβ)-induced neuroinflammation plays a prominent and early role in Alzheimer’s disease (AD). In this study, we

【作者】

：

Juliang Qin Xiaoyu Zhang Ziqia

【机构】

：

ShanghaiKeyLaboratoryofRegulatoryBiology

【出处】

：

中国科学：生命科学英文版

【发表日期】

：

2017年2期

【关键词】

：

Β-淀粉样蛋白 P2X7 受体表达炎症反应脑损伤诱导小胶质细胞 IL-1β Presenilin 2 P2X7 Alzheimer＇s diseas

【基金项目】

：

supported by the National Natural Science Foundation of China (31470040, 31570896, 81172816, 81672811),,Doctoral Fund of Ministry of Education of China (20130076110013),,Science and Technology Commiss

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Accumulating evidence suggests that β-amyloid (Aβ)-induced neuroinflammation plays a prominent and early role in Alzheimer’s disease (AD). In this study, we demonstrated that Presenilin 2 (PS2) deficiency facilitates Aβ-induced neuroinflammation and injur

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Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 ex

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