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肾小球足细胞裂孔隔膜(slit diaphragm,SD)是肾小球滤过屏障的重要结构和功能单位,在防止蛋白尿的发生中起着重要作用。SD蛋白质是SD的重要组成成分,在维持SD的结构和功能的完整性方面发挥着关键性作用,并且与蛋白尿的发生密切相关。深入研究SD蛋白质在蛋白尿发生发展过程中的作用机制,可有助于发现治疗蛋白尿的新靶点,从而更好地设计蛋白尿的早期诊断与治疗方案,为预防肾病综合征提供新的策略。
The glomerular podocyte slit diaphragm (SD) is an important structural and functional unit of the glomerular filtration barrier and plays an important role in preventing the occurrence of proteinuria. SD protein is an important component of SD and plays a key role in maintaining the structural and functional integrity of SD and is closely related to the occurrence of proteinuria. In-depth study of the mechanism of action of SD protein in the development and progression of proteinuria may help to discover new targets for proteinuria, so as to better design the early diagnosis and treatment of proteinuria and provide a new method for the prevention of nephrotic syndrome Strategy.