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目的:探讨2型糖尿病合并非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)患者发生颈动脉粥样硬化的临床特点及危险因素。方法:350例2型糖尿病患者,根据是否合并NAFLD分为2型糖尿病无NAFLD组(A组)164例和2型糖尿病合并NAFLD组(B组)186例,比较2组脂代谢紊乱及颈动脉粥样硬化程度。结果:B组体质量指数、腰围,三酰甘油、总胆固醇、谷氨酸转氨酶及门冬氨酸氨基转移酶水平均高于A组(P<0.05);2组空腹血糖、糖化血红蛋白、糖尿病病程、血压比较差异无统计学意义(P>0.05)。350例患者中188例(53.71%)伴不同程度的颈动脉粥样硬化;B组与A组比较,颈动脉粥样硬化患病率高,颈动脉内膜-中层厚度明显增厚,差异有统计学意义(P<0.05)。结论:2型糖尿病患者NAFLD及颈动脉粥样硬化发病率均较高,合并NAFLD的2型糖尿病患者易发生颈动脉粥样硬化。
Objective: To investigate the clinical features and risk factors of carotid atherosclerosis in type 2 diabetic patients with nonalcoholic fatty liver disease (NAFLD). Methods: A total of 350 patients with type 2 diabetes mellitus (DM) were divided into two groups according to whether NAFLD was combined: 164 patients with type 2 diabetes without NAFLD (group A) and 186 patients with type 2 diabetes and NAFLD (patient B). The lipid metabolism disorder and carotid artery Atherosclerosis degree. Results: The body mass index, waist circumference, triglyceride, total cholesterol, glutamate aminotransferase and aspartate aminotransferase in group B were significantly higher than those in group A (P <0.05). The fasting blood glucose, glycosylated hemoglobin, There was no significant difference in duration and blood pressure (P> 0.05). There were 188 cases (53.71%) with carotid atherosclerosis in 350 cases. The carotid atherosclerosis in group B was higher than that in group A, and the carotid intima-media thickness was significantly thicker in group B Statistical significance (P <0.05). Conclusion: The incidence of NAFLD and carotid atherosclerosis are both higher in patients with type 2 diabetes. Carotid atherosclerosis is more likely to occur in type 2 diabetic patients with NAFLD.