Construction of the Oxetane Ring from 5α-Acyloxy-Δ~(4(20))-taxoids

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-An oxetane ring can be constructed from 5 α-acyloxy-Δ4(20) -taxoids with osmylation as the first step in the usual manner. The innovation reported here is the use of an intramolecularly available acyl group for the protection of 20-OH by an unexpected 5-to 20-migration under slightly basic conditions. -An oxetane ring can be constructed from 5 α-acyloxy-Δ4 (20) -taxoids with osmylation as the first step in the usual manner. The innovation reported here is the use of an intramolecularly available acyl group for the protection of 20-OH by an unexpected 5-to 20-migration under slightly basic conditions.
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