论文部分内容阅读
本文将a1受体拮抗剂(±)-DDPH用(+)-酒石酸和(-)-二苯甲酰酒石酸为拆分剂拆分为(+)-DDPH体和(-)-DDPH。(-)-DDPH和(±)-DDPH拮抗a1受体激动剂苯肾上腺素作用强度相近,PA2值分别为7.69和7.55。
In this paper, the (+) - DDPH and (-) - DDPH were resolved by using (+) - tartaric acid and (-) - dibenzoyltartaric acid as the resolving agent. The intensity of (-) - DDPH and (±) -DDPH antagonistic a1 receptor agonist phenylephrine was similar, with PA2 values of 7.69 and 7.55, respectively.