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以SD雌性大鼠 7周递增负荷跑台运动为运动性闭经模型 ,分别测定了 7周、5周、3周各阶段递增负荷后的体重、血红蛋白、垂质比、心质比、阴道脱落细胞的变化。结果表明 :(1)持续递增负荷运动可使大鼠动情周期抑制 ,并且饮食量、体重、血红蛋白、阴道脱落细胞的变化与运动员相同。因此 ,用大鼠建立运动性闭经 (ASA)的模型是可行的。 (2 )大鼠动情周期抑制时 ,饮食量下降 ,体重下降 ,血红蛋白减少 ,垂质比变小而心质比变大 ,阴道脱落细胞以底、中层细胞为主。提示这些变化与ASA密切相关。 (3)在持续递增负荷运动时 ,动情周期抑制是逐渐发生的 ,且停训后短时间内阴道脱落细胞不能完全右移。
The rats were randomly divided into three groups: SD rats with 7-week incremental treadmill exercise and exercise-induced amenorrhea model. The body weight, hemoglobin, pituitary, heart rate and vaginal exfoliated cells The change. The results showed that: (1) The continuous escalation of stress exercise could inhibit the estrous cycle in rats, and the changes of diet, body weight, hemoglobin and vaginal exfoliated cells were the same as those of athletes. Therefore, it is feasible to establish a model of motor amenorrhea (ASA) in rats. (2) When the estrous cycle was inhibited in rats, the diet decreased, body weight decreased, decreased hemoglobin, reduced the ratio of pituitary to the ratio of cardiac mass, vaginal exfoliated cells in the bottom and middle layer cells. Suggesting that these changes are closely related to the ASA. (3) During the continuous increasing load exercise, the inhibition of estrous cycle gradually occurs, and the vaginal exfoliated cells can not move completely to the right after stop training.