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目的:探讨高压氧对新生儿缺氧缺血性脑病(HIE)患儿恢复期治疗的临床疗效。方法:将126例诊断为HIE的患儿随机分成治疗组(HBO)66例和对照组60例,进行比较观察。采用影像学头颅CT及神经、精神运动发育行为测定(NBNA、CDCC)对治疗后患儿智力发育指数(MDI)、运动发育指数(PDI)、后遗症进行评估。结果:治疗组较对照组患儿MDI、PDI明显提高,且后遗症少,具有显著的临床疗效。结论:高压氧对HIE患儿恢复期促进神经细胞的恢复具有一定的临床疗效。
Objective: To investigate the clinical effect of hyperbaric oxygen therapy on convalescence of neonates with hypoxic-ischemic encephalopathy (HIE). Methods: 126 children diagnosed as HIE were randomly divided into treatment group (HBO) 66 cases and control group 60 cases, for comparative observation. The mental development index (MDI), motor development index (PDI) and sequelae of children after treatment were evaluated by imaging cranial CT and neurological and psychomotor developmental behavioral testing (NBNA, CDCC). Results: Compared with the control group, the MDI and PDI in the treatment group were significantly increased, and the sequelae were less, with significant clinical efficacy. CONCLUSION: Hyperbaric oxygen has certain clinical effect on recovery of neural cells in convalescent HIE children.