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目的:评价血清胱抑素C在不同程度肾积水肾功能损害诊断中的临床意义。方法:用ELISA法测定不同程度肾积水患者血清胱抑素C同时用酶法检测这些患者血清肌酐(Scr)、尿素氮(BUN)。以放射性核素99mTc-DTPA测得的肾小球滤过率(GFR)作为诊断评价的金标准。结果:轻度肾积水、中度肾积水、重度肾积水患者两两间血清有显著差异(P<0.01),且均与对照组有显著差异(P<0.01);不同程度肾积水患者血清胱抑素C、Scr、BUN均与GFR有相关性(P<0.01),胱抑素C与GFR相关系数最大(P<0.01)。结论:血清胱抑素C可作为单独评价GFR的敏感性指标,为检测肾功能提供了精确、可靠的指标。
Objective: To evaluate the clinical significance of serum cystatin C in the diagnosis of hydronephrosis with different degrees of hydronephrosis. Methods: Serum levels of cystatin C in patients with hydronephrosis were measured by ELISA. Serum creatinine (Scr) and blood urea nitrogen (BUN) were detected by enzymatic method. Glomerular filtration rate (GFR) measured with radionuclide 99mTc-DTPA served as the gold standard for diagnostic evaluation. Results: There was a significant difference (P <0.01) between the two groups of patients with mild hydronephrosis, moderate hydronephrosis and severe hydronephrosis, and there were significant differences between the two groups (P <0.01) Serum levels of cystatin C, Scr and BUN in patients with water were correlated with GFR (P <0.01), and the correlation coefficient between cystatin C and GFR was the highest (P <0.01). Conclusion: Serum cystatin C can be used as a sensitive index for evaluating GFR alone, providing an accurate and reliable indicator for detecting renal function.