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[目的]探讨胃癌组织中胸苷酸合成酶(TS)的表达及其对胃癌患者化疗敏感性的预测价值。[方法]60例胃癌患者均接受2个周期DDP/5-Fu化疗。DDP15~20 mg/(m2.d)静脉滴注d1~5;5-Fu 375~500 mg/(m2.d)静脉滴注8 h,d1~5,休息4周后,进行第2个周期化疗。采用免疫组织化学染色法(SP法)检测60例胃癌胃黏膜石蜡标本中TS的表达情况。[结果]60例胃癌标本中TS蛋白高表达者29例(48.3%),低表达者31例(51.7%);TS低表达患者的化疗有效率(64.5%)明显高于TS高表达者(34.5%)(P<0.05)。[结论]胃癌组织中TS蛋白表达水平对应用DDP/5-Fu治疗胃癌的疗效具有一定预测价值。
[Objective] To investigate the expression of thymidylate synthase (TS) in gastric cancer tissue and its predictive value in chemosensitivity of gastric cancer patients. [Method] 60 patients with gastric cancer received 2 cycles of DDP / 5-Fu chemotherapy. DDP 15 ~ 20 mg / (m2.d) intravenous drip d1 ~ 5; 5-Fu 375 ~ 500 mg / (m2.d) intravenous drip 8 h, d1 ~ 5, resting for 4 weeks, the second cycle Chemotherapy. Immunohistochemical staining (SP method) was used to detect the expression of TS in 60 cases of gastric cancer gastric mucosa. [Results] Twenty-nine patients (48.3%) had TS protein overexpression and 31 patients (51.7%) had low TS protein expression in 60 cases of gastric cancer. The effective rate of chemotherapy (64.5%) in patients with TS low expression was significantly higher than that in TS high expression 34.5%) (P <0.05). [Conclusion] The expression of TS protein in gastric cancer tissue has some predictive value for the treatment of gastric cancer with DDP / 5-Fu.