目的探讨CT引导下经皮肺穿刺活检在延迟吸收性肺炎、慢性肺炎及难治性肺炎诊断中的临床意义。方法选择我院自2014年1月~2015年5月符合标准的71例消散延迟性肺炎、慢性肺炎与难治性肺炎患者,分为非肺穿活检组(A组,n=29)和CT引导下肺穿活检组(B组,n=42),CT引导下肺穿活检组根据肺穿活检结果予对应治疗。结果 CT引导下肺穿活检组病原学检查阳性率达42.85%,确诊率达73.81%,平均住院日明显缩短、平均住院费用明显降低、抗生素应用时间缩短、药物不良反应减少,两组统计学差异明显(P<0.05)。结论依据CT引导下肺穿活检结果有针对性地指导治疗,可以明显缩短治疗疗程,有效减少患者药物不良反应,降低患者平均住院费用,取得了良好的经济效益和社会效益。 Objective To investigate the clinical significance of CT-guided percutaneous lung biopsy in the diagnosis of delayed-absorption pneumonia, chronic pneumonia and refractory pneumonia. Methods Seventy-one patients with delayed-onset pneumonia, chronic pneumonia and refractory pneumonia who met the criteria from January 2014 to May 2015 in our hospital were divided into non-lung biopsy group (group A, n = 29) and CT Under the guidance of the lung biopsy group (B group, n = 42), CT guided lung biopsy group according to the results of lung biopsy to the corresponding treatment. Results The positive rate of pulmonary biopsy under the guidance of CT was 42.85% and the diagnosis rate was 73.81%. The average length of stay was significantly shortened, the average cost of hospitalization was significantly reduced, antibiotic application time was shortened, and adverse drug reactions were decreased. There was statistical difference between the two groups Obviously (P <0.05). Conclusion According to CT-guided lung biopsy results guided therapy, can significantly shorten the course of treatment, reduce adverse drug reactions in patients, reduce the average hospitalization costs, and achieved good economic and social benefits.