自从发现胃肠道粘膜中广泛存在内分泌系统以来,有文献报道在糖尿病、萎缩性胃炎和乳糜泻等病人中有抗多种胃肠道肽激素分泌细胞的自身抗体,提示可能有自身体液免疫存在。本文作者对一些肠病患者和非肠病患者检测了抗胃肠道肽激素分泌细胞的自身抗体,并对结果作了分析。方法:研究对象268例,男性115例,女性153例。其中乳糜泻43例,疱疹性皮炎24例(10例伴乳糜泻),克隆氏病47例,溃疡性结肠炎65例和肠道易激综合征44例;另30例无肠病依据,15人为正常健康者。取血清标本检测胃肠内分泌细胞自身抗体,阳性者中20例于8～18月内重复测定。“正常”肠粘膜取材于0型血外科手术病人的非病变肠段;十二指肠、空肠、回肠和结肠组织来自不同供体。应用免疫荧光法检测自身抗体和鉴定胃肠内分泌 Since the discovery of an endocrine system widely found in the gastrointestinal mucosa, it has been reported in the literature that autoantibodies to various gastrointestinal peptide secreting cells in patients with diabetes, atrophic gastritis and celiac disease suggest that there may be self humoral immunity . The authors tested autoantibodies against gastrointestinal peptide-producing hormone-secreting cells in some enteropathy patients and non-enteropathy patients and analyzed the results. Methods: 268 subjects were studied, 115 males and 153 females. Among them, 43 cases of celiac disease, 24 cases of herpetic dermatitis (10 cases with celiac disease), 47 cases of Crohn’s disease, 65 cases of ulcerative colitis and 44 cases of irritable bowel syndrome; the other 30 cases without enteropathy, 15 Artificial normal people. Serum samples were taken to detect gastrointestinal endocrine cells autoantibodies, 20 were positive in 8 to 18 months repeated determination. The “normal” intestinal mucosa is drawn from the non-diseased bowel segment of patients with type 0 blood surgery; the duodenum, jejunum, ileum and colon tissues are from different donors. Autoimmunofluorescence was used to detect autoantibodies and identify gastrointestinal endocrine