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干扰素/维甲酸联合应用诱导细胞凋亡相关的基因19(gene associated with retinoid-interferon-induced mortality-19,GRIM-19)是一种新的抑癌基因,通过多种机制参与细胞凋亡,是信号转导及转录活化因子3(signal transducers and activators of transcription 3,STAT3)的特异性抑制蛋白,在多种肿瘤组织中低表达。STAT3及其介导的信号转导通路参与调节细胞的增殖、凋亡与分化,介导细胞的恶性转化,并与肿瘤的发生发展关系密切。恢复GRIM-19的表达通过抑制STAT3的表达和激活而显著抑制肿瘤细胞的生长。
Interferon / retinoic acid combined with the application of induced apoptosis-associated gene 19 (GRIM-19) is a novel tumor suppressor gene, through a variety of mechanisms involved in apoptosis, Is a specific inhibitor of signal transducers and activators of transcription 3 (STAT3), which is down-regulated in many tumor tissues. STAT3 and its signal transduction pathway are involved in the regulation of cell proliferation, apoptosis and differentiation, and mediate the malignant transformation of cells, and are closely related to the occurrence and development of tumors. Restoring the expression of GRIM-19 significantly inhibits the growth of tumor cells by inhibiting the expression and activation of STAT3.