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[目的]观察脑疏宁对脑出血急性期大鼠的神经功能缺损、脑水肿的改善作用及其作用机制。[方法]将84只大鼠随机分为假手术组、脑出血组、脑疏宁低剂量组、脑疏宁中剂量组、脑疏宁高剂量组及甘露醇组,采用自体血回输方法建立大鼠脑出血模型,进行脑出血24h和48h后大鼠神经功能评分、木条行走作业能力和脑组织含水量测定。[结果]脑疏宁中剂量和高剂量对脑出血后神经功能缺损有明显改善作用;脑出血后48h脑疏宁中剂量和高剂量组的木条行走时间明显短于模型组且显著优于低剂量组;脑疏宁各治疗组与甘露醇组脑含水量明显低于模型组,与低剂量组相比,脑疏宁高剂量和甘露醇组的脑组织含水量明显降低。[结论]脑疏宁对大鼠脑出血后神经功能恢复和脑水含量均具有明显的改善作用,其作用机制可能是减轻血管源性脑水肿。
[Objective] To observe the ameliorative effect of Naoshuning on neurological deficit and cerebral edema in rats with acute cerebral hemorrhage and its mechanism. [Methods] 84 rats were randomly divided into sham operation group, intracerebral hemorrhage group, Naoshunning low-dose group, Naoshunning middle-dose group, Naoshouning high-dose group and mannitol group, using autologous blood transfusion method. A rat model of cerebral hemorrhage was established, and neurological function scores, walking ability of wood strips, and water content of brain tissue were measured 24h and 48h after intracerebral hemorrhage. [Results] The middle-dose and high-dose Ningshouning had a significant effect on the improvement of neurological deficits after cerebral hemorrhage; the walking time of the wood strips in the middle and middle doses of Ningshuning at 48h after cerebral hemorrhage was significantly shorter than that of the model group and was significantly better than that of the model group. In the low-dose group, the brain water content of the brain sulfation group and the mannitol group was significantly lower than that of the model group. Compared with the low-dose group, the water content of the brain in the high-dose and mannitol groups of Naoshuning was significantly reduced. [Conclusion] Naoshuning has obvious improvement effect on neurological recovery and brain water content after intracerebral hemorrhage in rats, and its mechanism may be to reduce vasogenic brain edema.