The extraction process of gold and silver from the gold clay ore containing arsenic and manganese was investigated.With the conventional technique,the leaching rates of gold and silver are 78.23%and 49.02%,respectively.To eliminate the negative effects of arsenic and manganese on cyanidation and increase the gold and silver leaching rates,a novel catalyst was added.The content of the catalyst used in the process was 8 g per 500 g org sample,the sample size was 60μm and the pH value was kept between 10 and 11.Leaching with the catalyst for 3-5 h under certain conditions,the gold leaching rate increased to over 90%and the silver leaching rate increased to 80%-90%.The catalyst can effectively liberate gold and silver from the enclosure of arsenic and manganese and the industrial experiment has great significance to the development and utilization of the gold clay ore containing arsenic and manganese. The extraction process of gold and silver from the gold clay ore containing arsenic and manganese was investigated. Since the conventional technique, the leaching rates of gold and silver are 78.23% and 49.02% respectively. Eliminate the negative effects of arsenic and manganese on cyanidation and increase the gold and silver leaching rates, a novel catalyst was added. The content of the catalyst used in the process was 8 g per 500 g org sample, the sample size was 60 μm and the pH value was kept between 10 and 11. Leaching with the catalyst for 3-5 h under certain conditions, the gold leaching rate increased to over 90% and the silver leaching rate increased to 80% -90%. The catalyst can effectively liberate gold and silver from the enclosure of arsenic and manganese and the industrial experiment has great significance to the development and utilization of the gold clay ore containing arsenic and manganese.